PGC-1α is upregulated during exercise, and is targeted by calcineurin signalling to promote the specialization of adult muscle fibres (Box 2). The role of PGC-1α as a regulator of the slow-muscle The functional assessment of a cancer stem cell requires not only the ability to form a new tumour, but to recapitulate precisely the phenotype of the initial disease (Box 1). Based on functional and In the sections below, the molecular pathways guiding some of the transitions that take place during the development of the heart and that are outlined in Box 2 will be described migratory events Box 1: Perfusion-independent role of endothelial cells During embryogenesis, the invasion of endothelial cells into nascent organs confers inductive signals to promote organogenesis, even in the MVBs fuse with the vacuole/lysosome and the vesicles and their contents are degraded by the hydrolases that are contained in the lumen of the vacuole/lysosome. A crucial function of the MVB protein E, number of days gestation; FoxA, Forkhead box A; GATA, GATA-binding proteins. + indicates the presence of the protein. Considering that there is a well-defined window when HHEX, NKX3-2, PTF1A–RBPJ .
These studies have suggested that complementary changes in ancestral genetic networks, together with the emergence of new networks, enabled unprecedented Delta–Notch signalling between pharyngeal .
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